BRAF mutation
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BRAF mutation is a common genetic change in cancer.
General
- BRAF inhibitors (e.g. vemurafenib) is used to treat BRAF mutation positive tumours.[1]
- BRAF mutations in ~ 50% of melanomas; respond to BRAF inhibitors.
- BRAF mutations in ~ 10% of colorectal tumours.
- Poor prognosticator, poor response to chemotherapy, typically right sided tumours.
- BRAF mutations in ~45-50% of papillary thyroid carcinoma.
- BRAF mutations in ~3% of lung adenocarcinomas.
References
- ↑ Cheng, L.; Lopez-Beltran, A.; Massari, F.; MacLennan, GT.; Montironi, R. (01 2018). "Molecular testing for BRAF mutations to inform melanoma treatment decisions: a move toward precision medicine.". Mod Pathol 31 (1): 24-38. doi:10.1038/modpathol.2017.104. PMID 29148538.