TRK fusions

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TRK fusions are seen in many solid tumours and have targeted drugs.

Genes:

  • TRK1
  • TRK2
  • TRK3

The TRK genes are tyrosine kinase receptors.

Multiple fusion partners for each gene.

Association

  • MASC.
  • Secretory breast carcinoma.

Drugs

  • Merestinib.
  • Larotrectinib.
  • Others.

See also

References

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