Tissue microarray

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A tissue microarray (often abbreviated: TMA) is a paraffin block (recipient) with cylindrical tissue biopsies taken from individual tissue samples (donors).

The method was introduced by Kononen et al. in 1998 [1] and is widely used in pathology especially in tumor analysis.

  • Tissue microarray block.

  • Tissue microarray slide

  • Example of tissue cross-reactivity on human tissue microarray.jpeg

    IHC stains on TMA

  1. ↑ Kononen, J.; Bubendorf, L.; Kallioniemi, A.; Bärlund, M.; Schraml, P.; Leighton, S.; Torhorst, J.; Mihatsch, MJ. et al. (Jul 1998). "Tissue microarrays for high-throughput molecular profiling of tumor specimens.". Nat Med 4 (7): 844-7. PMID 9662379.
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