Endometrium with changes due to selective progesterone receptor modulators

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Endometrium with changes due to selective progesterone receptor modulator may mimic endometrial hyperplasia.

Selective progesterone receptor modulators, abbreviated SPRMs, are a class of drugs that block the action of progesterone. They are used to treat uterine fibroids.[1]

General

  • Ulipristal - trade name Fibristal.
  • May be used as an emergency contraceptive.[2]

Microscopic

Features:[1]

  • Glandular changes - extensive cystic dilatation.
  • Inactive appearing glandular epithelium or abortive subnuclear vacuolization.
  • Rare mitoses and apoptosis.
  • Abnormal stromal vessels - common.

DDx:

See also

References

  1. ↑ 1.0 1.1 Williams, AR.; Bergeron, C.; Barlow, DH.; Ferenczy, A. (Nov 2012). "Endometrial morphology after treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate.". Int J Gynecol Pathol 31 (6): 556-69. doi:10.1097/PGP.0b013e318251035b. PMID 23018219.
  2. ↑ Whitaker, LH.; Williams, AR.; Critchley, HO. (Aug 2014). "Selective progesterone receptor modulators.". Curr Opin Obstet Gynecol 26 (4): 237-42. doi:10.1097/GCO.0000000000000082. PMID 24950125.
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