Human papillomavirus-related multiphenotypic sinonasal carcinoma

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Human papillomavirus-related carcinoma with adenoid cystic-like features, abbreviated HPV-related carcinoma with AdCC-like features.

General

  • Very rare diagnosis - recently described.[1]

Microscopic

Features:

  • Adenoid cystic carcinoma-like morphology with:
    • Squamous dysplasia of surface epithelium
    • Squamous dfferentiation within tumour

Notes:

  • Perineural invasion rare.
  • Bony invasion rare.

DDx:

IHC

  • p16 +ve.

References

  1. ↑ Bishop, JA.; Ogawa, T.; Stelow, EB.; Moskaluk, CA.; Koch, WM.; Pai, SI.; Westra, WH. (Jun 2013). "Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract.". Am J Surg Pathol 37 (6): 836-44. doi:10.1097/PAS.0b013e31827b1cd6. PMID 23598962.
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