Paneth cell-like change of the prostate gland

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Paneth cell-like change of the prostate gland. H&E stain. (WC/Nephron)

Paneth cell-like change of the prostate gland, abbreviated PCLC, is an uncommon histologic change in the prostate gland that may be seen in the context of benign or malignant glands.[1][2]

Microscopic

Features:

  • Prostatic glands with a Paneth gland-like appearance:
    • Eosinophilic cytoplastic granules.

Images

  • PCLC - intermed. mag.

  • PCLC - high mag.

  • PCLC - very high mag.

See also

References

  1. ↑ Weaver, MG.; Abdul-Karim, FW.; Srigley, J.; Bostwick, DG.; Ro, JY.; Ayala, AG. (Jan 1992). "Paneth cell-like change of the prostate gland. A histological, immunohistochemical, and electron microscopic study.". Am J Surg Pathol 16 (1): 62-8. PMID 1370193.
  2. ↑ Adlakha, H.; Bostwick, DG. (Feb 1994). "Paneth cell-like change in prostatic adenocarcinoma represents neuroendocrine differentiation: report of 30 cases.". Hum Pathol 25 (2): 135-9. PMID 7509774.
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