Leydig cell hyperplasia

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Leydig cell hyperplasia is an uncommon benign pathology of the testis.[1] It may be seen in the ovary.

General

Gross

  • Unremarkable.

Note:

  • Hypoechoic lesions on ultrasound.[2]

Microscopic

Features:

  • Abundant Leydig cells interspersed between seminiferous tubules with only Sertoli cells.
  • Do not displace or compress the seminiferous tubules.

Note:

  • May form nodules up to 6 mm.[1]

DDx:

See also

References

  1. 1.0 1.1 Carucci, LR.; Tirkes, AT.; Pretorius, ES.; Genega, EM.; Weinstein, SP. (Feb 2003). "Testicular Leydig's cell hyperplasia: MR imaging and sonographic findings.". AJR Am J Roentgenol 180 (2): 501-3. doi:10.2214/ajr.180.2.1800501. PMID 12540460.
  2. 2.0 2.1 Sterbis, J.; E-Nunu, T. (2015). "Leydig cell hyperplasia in the setting of Klinefelter syndrome.". BMJ Case Rep 2015. doi:10.1136/bcr-2015-209805. PMID 26209412.