Chromosomal translocations

From Libre Pathology
Revision as of 05:16, 9 March 2011 by Michael (talk | contribs) (tweak gr.)
Jump to navigation Jump to search

Chromosomal translocations, also translocations, may be characteristic of a tumour or simply narrow down the diagnosis to a set of tumours.

Key point

The key point is:

  • One should be aware of the existence of specific (i.e. diagnostic/near diagnostic) translocations and translocations which significantly narrow down the diagnosis -- which are available to (clinical) pathologists.

Unfortunate reality of residency

Translocations are often a subject of pimping and show-up on examinations.

List of translocations

Translocation Genes Tumour(s) Reference
t(12;16) FUS/ATF1 angiomatoid fibrous histiocytoma [1]
t(12;22) EWS/ATF1 angiomatoid fibrous histiocytoma [1]
t(12;16) EWS/CHOP myxoid liposarcoma [1]
t(16;22) EWS/ATF1 myxoid liposarcoma [1]
t(12;22) EWS/ATF1 clear cell sarcoma [1]
t(21;22) EWS/ATF1 Ewing sarcoma [1]
t(12;21) FUS/ERG Ewing sarcoma [1]
t(12;21) FUS/ERG acute myeloid leukemia [1]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 PST. 14 February 2011.
Retrieved from "https://librepathology.org/w/index.php?title=Chromosomal_translocations&oldid=4385"