Multilocular cystic renal neoplasm of low malignant potential
| Multilocular cystic renal neoplasm of low malignant potential | |
|---|---|
| Diagnosis in short | |
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| Synonyms | multilocular clear cell renal cell carcinoma, multilocular cystic renal cell neoplasm of low malignant potential (proposed name) |
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| LM | thin septa with (polygonal) cells with a clear cytoplasm, fibrous capsule (surrounds tumour), +/-calcification |
| LM DDx | cystic renal disease with macrophages in the septa, cystic clear cell renal cell carcinoma, tubulocystic carcinoma |
| Gross | completely cystic - no solid components, well-circumscribed |
| Site | kidney - see kidney tumours |
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| |
| Prevalence | rare (case reports) |
| Prognosis | very good |
| Clin. DDx | other cystic renal tumours (e.g. cystic clear cell renal cell carcinoma), cystic renal disease |
Multilocular cystic renal cell carcinoma, abbreviated MCRCC, is a rare kidney tumour.
It is also known as multilocular clear cell renal cell carcinoma.[1]
As the behaviour of the tumour is very good, it has be proposed that this entity be renamed multilocular cystic renal cell neoplasm of low malignant potential.[2]
General
- No recurrences or metastasis in the literature.[3]
- Case report rare.[4]
- May represent a subtype of clear cell renal cell carcinoma.[5]
Gross
Features:[3]
- Completely cystic with thin septa.
- No solid nodules - required for diagnosis.[6]
- Well circumscribed.
Note:
- This tumour, radiologically, can often be separated from other cystic tumours.[7]
Microscopic
- Thin septa with (polygonal) cells with a clear cytoplasm - required.
- Fibrous capsule (surrounds tumour) - required.
- +/-Calcification (common).
DDx:
- Renal cyst lined by clear cells - do not have clear cells within the wall of the cyst.[8]
- Cystic renal disease with macrophages in the septa.
- Cystic clear cell renal cell carcinoma.
- Tubulocystic carcinoma.
Images
www:
- MCRCC (archivesofpathology.org).[1]
- MCRCC - low mag. (karger.com).[9]
- MCRCC - high mag. (karger.com).[9]
IHC
- EMA +ve.
- Keratins +ve.
- CD68 -ve.
Note:
See also
References
- ↑ 1.0 1.1 Chowdhury, AR.; Chakraborty, D.; Bhattacharya, P.; Dey, RK. (Apr 2013). "Multilocular cystic renal cell carcinoma a diagnostic dilemma: A case report in a 30-year-old woman.". Urol Ann 5 (2): 119-21. doi:10.4103/0974-7796.110012. PMID 23798872.
- ↑ Montironi, R.; Mazzucchelli, R.; Scarpelli, M.; Lopez-Beltran, A.; Cheng, L. (Dec 2013). "Update on selected renal cell tumors with clear cell features. With emphasis on multilocular cystic clear cell renal cell carcinoma.". Histol Histopathol 28 (12): 1555-66. PMID 23893851.
- ↑ 3.0 3.1 3.2 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 292. ISBN 978-0781765275.
- ↑ Agarwal, S.; Agrawal, U.; Mohanty, NK.; Saxena, S. (Mar 2011). "Multilocular cystic renal cell carcinoma: a case report of a rare entity.". Arch Pathol Lab Med 135 (3): 290-2. doi:10.1043/2010-0243-LE.1. PMID 21366448.
- ↑ Halat, S.; Eble, JN.; Grignon, DJ.; Lopez-Beltran, A.; Montironi, R.; Tan, PH.; Wang, M.; Zhang, S. et al. (Jul 2010). "Multilocular cystic renal cell carcinoma is a subtype of clear cell renal cell carcinoma.". Mod Pathol 23 (7): 931-6. doi:10.1038/modpathol.2010.78. PMID 20348877.
- ↑ 6.0 6.1 Eble, JN.; Bonsib, SM. (Feb 1998). "Extensively cystic renal neoplasms: cystic nephroma, cystic partially differentiated nephroblastoma, multilocular cystic renal cell carcinoma, and cystic hamartoma of renal pelvis.". Semin Diagn Pathol 15 (1): 2-20. PMID 9503503.
- ↑ You, D.; Shim, M.; Jeong, IG.; Song, C.; Kim, JK.; Ro, JY.; Hong, JH.; Ahn, H. et al. (Jul 2011). "Multilocular cystic renal cell carcinoma: clinicopathological features and preoperative prediction using multiphase computed tomography.". BJU Int. doi:10.1111/j.1464-410X.2011.10247.x. PMID 21722289.
- ↑ Epstein, Jonathan I.; Netto, George J. (2014). Differential Diagnoses in Surgical Pathology: Genitourinary System (1st ed.). Wolters Kluwer. pp. 197. ISBN 978-1451189582.
- ↑ 9.0 9.1 Tantisattamo, E.; Elam, A.; Cobb, J.; Ellis, CL.; Bailey, JL. (2014). "No tumor-free waiting period after treatment of multilocular cystic renal cell carcinoma: a new case and review of the literature.". Am J Nephrol 40 (2): 151-6. doi:10.1159/000365201. PMID 25171490.
- ↑ Williamson, SR.; Halat, S.; Eble, JN.; Grignon, DJ.; Lopez-Beltran, A.; Montironi, R.; Tan, PH.; Wang, M. et al. (Oct 2012). "Multilocular cystic renal cell carcinoma: similarities and differences in immunoprofile compared with clear cell renal cell carcinoma.". Am J Surg Pathol 36 (10): 1425-33. doi:10.1097/PAS.0b013e31825b37f0. PMID 22982885.