Cytokeratin 7
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CK7 immunostain in acinar adenocarcinoma of the lung.
Cytokeratin 7, also keratin 7 and CK7, is a common low molecular keratin and a very common immunostain.[1]
Positive
Classic positive
- Ovary.
- Breast.
- Endometrium.
- Salivary gland.
- Lung (adenocarcinoma, small cell).
- Thyroid.
- Mesothelium.
Negative
Classic negative
- Kidney[1] (clear cell renal cell carcinoma). ‡
- Colon and rectum.[1]
- Prostate.[1]
- Thymus.[1]
- Squamous cell carcinoma.
Notes:
- ‡ Most other common types are CK7 +ve (papillary RCC, chromophobe RCC, clear cell papillary RCC)
See also
References
- ↑ Jump up to: 1.0 1.1 1.2 1.3 1.4 Chu, P.; Wu, E.; Weiss, LM. (Sep 2000). "Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases.". Mod Pathol 13 (9): 962-72. doi:10.1038/modpathol.3880175. PMID 11007036.