Histiocytoses

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Histiocytoses, singular histiocytosis, are a rare set of conditions affecting tissue macrophages.

Histiocytoses in a table

Features of histiocytoses:[1]

Histologic features EM features CD68 S-100 CD1a Image
Macrophage epithelioid cells, giant cells - + - - Macrophages - CD68 (WC)
Erdheim-Chester disease Touton giant cells - + +/- -
Rosai-Dorfman Emperipolesis - + + - RDD (WC)
Langerhans cell histiocytosis Reniform nuclei,
eosinophilic cytoplasm
Birbeck granules + + + LCH (WC)

Notes:

  • EM = electron microscopy.

Langerhans cell histiocytosis

IHC

Langerin (CD207).[2]

See also

References

  1. Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Oberman, Harold A; Reuter, Victor E (2004). Sternberg's Diagnostic Surgical Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 479. ISBN 978-0781740517.
  2. URL: http://www.ncbi.nlm.nih.gov/omim/604862. Accessed on: 2 February 2011.