Oligoastrocytoma

Oligoastrocytoma is a rare neuropathology tumour.

General

• Mixed tumour.

Microscopic

Features:

• Astrocytoma-like and oligodendroglioma-like:
  1. Oligodendroglioma-like cells = round nucleus, peri-nuclear clearing.
  2. Astrocytoma-like cells = non-ovoid/elongated nucleus.

DDx:

• Anaplastic astrocytoma.
• Oligodendroglioma. (???)

IHC

• Oligodendroglioma-like cells: MAP-2 +ve (cytoplasm).
• Astrocytoma-like cells: GFAP +ve (cytoplasm, nuclear membrane).

Others:

• Ki-67 ~10%. (???)
• p53 - focally +ve. (???)
• IDH-1 +ve. (85%)

See also

• Neuropathology tumours.