Metaphyseal fibrous defect

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Template:Metaphyseal fibrous defect
Diagnosis in short

Synonyms Nonossifying fibroma
Clinical history Incidental radiograhic finding
Radiology Lucent defect


General

  • Common
  • Non-neoplastic
  • Self-limited
  • Skeletally immature individuals, children and adolescent
  • Often small lesions discovered an radiographic incidentaloma

Synonyms

  • Nonossifying fibroma (larger but otherwise identical)
  • Fibrous cortical defect
  • Fibrous metaphyseal defect
  • Fibroxanthoma of bone

Site

  • Metaphysis of distal femur or proximal tibia (80%)
  • Cortical
  • Metaphysis
  • Long bones
  • Eccentric location

Gross

Firm, granular, brown to yellow to red

Microscopic

Spindle cells without cytologic atypia are arranged in a storiform pattern with scattered chronic inflammatory cells and benign giant cells. Foam cells and hemosiderin deposition are present. Mitoses are seen but cytologic atypia is absent.

Differential Diagnosis

  • Giant cell tumor of bone (epiphyseal location, occurs in adults)

Relevant Diagnostic Groups

  • FOG MACHINES - acronym for radiographically lytic bone lesions Cite error: Invalid <ref> tag; invalid names, e.g. too many

Clinical history

  • Incidental radiographic finding
  • Pathologic fracture

Radiographic findings

Sharply demarcated, lucent, loculated, meta-diaphyseal lesion surrounded by a rim of sclerotic bone

Sign out

BONE; CURETTAGE: METAPHYSEAL FIBROUS DEFECT.

See also

References