Metaphyseal fibrous defect
| Template:Metaphyseal fibrous defect | |
|---|---|
| Diagnosis in short | |
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| |
| Synonyms | nonossifying fibroma |
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| |
| LM | spindle cells |
| LM DDx | giant cell tumor of bone |
| Syndromes | Jaffe-Campanacci syndrome |
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| |
| Clinical history | Incidental |
| Radiology | Lucent defect in the metaphysis |
General
- Common
- Non-neoplastic
- Self-limited
- Skeletally immature individuals, children and adolescent
- Often small lesions discovered an radiographic incidentaloma
Gross
Firm, granular, brown to yellow to red
Microscopic
Spindle cells without cytologic atypia are arranged in a storiform pattern with scattered chronic inflammatory cells and benign giant cells. Foam cells and hemosiderin deposition are present. Mitoses are seen but cytologic atypia is absent.
Stains
Not relevant.
IHC
Not relevant
Molecular
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See also
http://njms2.umdnj.edu/tutorweb/case8.htm http://www.pathologyoutlines.com/topic/bonemetaphysealfibrousdefect.html