Insular thyroid carcinoma
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Insular thyroid carcinoma, also insular carcinoma, is a rare clinically aggressive form of thyroid carcinoma.[1]
It may be lumped with papillary thyroid carcinoma.
General
Features:[2]
- Rare - approximately 5% of all thyroid carcinomas.
- Thought to be a separate tumour from papillary thyroid carcinoma and follicular thyroid carcinoma with a focal insular pattern.
- Some lump this entity with papillary carcinoma, i.e. consider it a variant of papillary thyroid carcinoma.
Microscopic
Features:[2]
- Islands of cells - key feature.
- Scant cytoplasm.
- Nuclei monomorphic and round.
DDx:[3]
- Medullary thyroid carcinoma.
- Poorly differentiated thyroid carcinoma.
Images
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See also
References
- ↑ Hod R, Bachar G, Sternov Y, Shvero J (2013). "Insular thyroid carcinoma: a retrospective clinicopathologic study". Am J Otolaryngol 34 (4): 292–5. doi:10.1016/j.amjoto.2012.12.009. PMID 23357591.
- ↑ 2.0 2.1 Rufini V, Salvatori M, Fadda G, et al. (September 2007). "Thyroid carcinomas with a variable insular component: prognostic significance of histopathologic patterns". Cancer 110 (6): 1209–17. doi:10.1002/cncr.22913. PMID 17665497.
- ↑ Endo. fellow. 17 September 2009.