Cystic medial degeneration

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Cystic medial degeneration (abbreviated CMD), also cystic medial necrosis,[1] is vascular pathology of the large blood vessels. It is suggestive of an underlying connective tissue disorder.

General

  • Nonspecific finding - may be seen in a number of conditions.
  • "Medial" refers to tunica media the middle (muscle) layer of an artery.

Note about cystic medial necrosis:

  • Often not cystic and not necrotic.

Microscopic

Features:[2][3]

  • Basophilic ground substance in the media (seen on Movat's stain).
  • Disruption of the elastic lamina (seen on elastic trichrome stain).
  • +/-Focal necrosis.

DDx:

Images

www:

Stains

Images

See also

References