Colorectal xanthomatous polyp

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The colorectal xanthomatous polyp, also colorectal xanthoma, is a rare benign intestinal polyp.

General

  • Rare.
  • May be associated with hyperlipidemia (7/25 patients in one series[1]).

Microscopic

Features:

  • Abundant foamy histiocytes in the superficial lamina propria.
  • +/-Superficial serrations (hyperplastic features).
    • Seen in ~80% of cases.[1]

DDx:

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POLYP, SIGMOID COLON, POLYPECTOMY:
- XANTHOMATOUS POLYP WITH HYPERPLASTIC FEATURES.
- NEGATIVE FOR DYSPLASIA.

COMMENT:
Xanthomatous polyps may be seen in the context of hyperlipidemia.

See also

References

  1. ↑ Jump up to: 1.0 1.1 Nakasono, M.; Hirokawa, M.; Muguruma, N.; Okahisa, T.; Okamura, S.; Ito, S.; Miyamoto, H.; Wada, S. et al. (Jan 2004). "Colorectal xanthomas with polypoid lesion: report of 25 cases.". APMIS 112 (1): 3-10. PMID 14961968.
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