Littoral cell angioma

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Littoral cell angioma, abbreviated LCA, is an uncommon benign vascular lesion of the spleen.

Angioma, in general, is dealt with in vascular malformations.

General

Features:[1]

  • Rare.
  • Benign.

Clinical:[1][2]

  • Pyrexia (fever), splenomegaly, weight loss, solitary hypodense lesion on imaging.

Note:

  • Littoral cells = line vascular channels of the red pulp.[1]
    • Littoral = related to shore.[3][4]

Microscopic

Features:[1]

  • Anastoming, small vascular channels.
  • Cystic spaces.
    • May have papillary projections.[2]

DDx:[1]

Images

  • LCA - very low mag. (WC)

  • LCA - low mag. (WC)

  • LCA - intermed. mag. (WC)

  • LCA - high mag. (WC)

  • LCA - very high mag. (WC)

www:

IHC

Features:[1]

  • CD68 +ve.
  • CD31 +ve

Others:

  • CD34 -ve.
  • Factor VIII +ve.

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Tan, YM.; Chuah, KL.; Wong, WK. (Jul 2004). "Littoral cell angioma of the spleen.". Ann Acad Med Singapore 33 (4): 524-6. PMID 15329769. http://www.annals.edu.sg/pdf200408/V33N4p524.pdf.
  2. ↑ 2.0 2.1 Dascalescu, CM.; Wendum, D.; Gorin, NC. (Sep 2001). "Littoral-cell angioma as a cause of splenomegaly.". N Engl J Med 345 (10): 772-3. doi:10.1056/NEJM200109063451016. PMID 11547761. http://www.nejm.org/doi/full/10.1056/NEJM200109063451016.
  3. ↑ URL: http://www.merriam-webster.com/dictionary/littoral. Accessed on: 24 July 2011.
  4. ↑ URL: http://dictionary.reference.com/browse/littoral. Accessed on: 24 July 2011.
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