Multiple endocrine neoplasia

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Multiple endocrine neoplasia, abbreviated MEN, refers to collection of different genetic abnormalities that lead to endocrine neoplasms.

Simple

MEN I

Memory device: 3 Ps.

MEN IIa/IIb (II/III)

  • Parathyroid adenoma.
  • Medullary thyroid carcinoma.
  • Pheochromocytoma.

Notes:

  • BOTH have parathyroid adenoma.
  • EACH has one below and one above the diaphragm.

Details

MEN IIa

  • Ganglioneuromatosis of the alimentary tract.[2][3]
    • Extra large nerves in GI tract.

Image: Ganglioneuromatosis - crappy images (wjso.com).

References

  1. ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2. Accessed on: 2 September 2010.
  2. ↑ URL: http://www.ncbi.nlm.nih.gov/omim/162300. Accessed on: 19 November 2010.
  3. ↑ Haraguchi M, Kinoshita H, Koori M, et al. (2007). "Multiple rectal carcinoids with diffuse ganglioneuromatosis". World J Surg Oncol 5: 19. doi:10.1186/1477-7819-5-19. PMC 1805501. PMID 17306015. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805501/.
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