Post-inflammatory pigment alteration

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Post-inflammatory pigment alteration, abbreviated PIPA, is benign dermal pigmentation change. It may be either hyperpigmentation or hypopigmentation.[1]

Post-inflammatory hyperpigmentation and post-inflammatory hypopigmentation redirect here.

General

Clinical DDx:

Gross

  • Hyperpigmentation or hypopigmentation.

Images:

Microscopic

Features:

  • Perivascular pigment incontinence.
  • No melanocytic nests.
  • No increase of melanocytes.

DDx:

Stains

See also

References

  1. Cardinali, G.; Kovacs, D.; Picardo, M. (Dec 2012). "Mechanisms underlying post-inflammatory hyperpigmentation: lessons from solar lentigo.". Ann Dermatol Venereol 139 Suppl 4: S148-52. doi:10.1016/S0151-9638(12)70127-8. PMID 23522630.