Serous cystadenoma of the ovary

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Serous cystadenoma of the ovary is a common benign finding in the ovary.

It is also known as ovarian serous cystadenoma. It is unrelated the the pancreatic serous cystadenoma.

Serous cystadenofibroma and adenofibroma of the ovary can be considered variants, and are also dealt with in this article.

General

Gross

  • Usually unilocular.

Image

Microscopic

Features:

  • Simple epithelium with cilia - key feature.
    • Cell morphology: columnar, cuboidal or flatted.

Note:

  • May have calcifications - uncommon.[3]

DDx:

Note - the following may be lumped with this entity:

  • Serous cystadenofibroma.
  • Adenofibroma.

Images

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OVARY, LEFT, CYSTECTOMY:
- BENIGN SEROUS CYSTADENOMA.
FALLOPIAN TUBE AND OVARY, LEFT, UNILATERAL SALPINGO-OOPHORECTOMY:
- OVARY WITH BENIGN SEROUS CYSTADENOFIBROMA.
- FALLOPIAN TUBE WITHIN NORMAL LIMITS.
- NEGATIVE FOR MALIGNANCY.
FALLOPIAN TUBE AND (PARTIAL) OVARY, LEFT, RESECTION:
- COMPATIBLE WITH SEROUS CYSTADENOMA.
- BENIGN OVARIAN PARENCHYMA WITH FOCAL EDEMA AND A BENIGN CALCIFICATION.
- FALLOPIAN TUBE WITHIN NORMAL LIMITS.
- NEGATIVE FOR MALIGNANCY.

Atypical

FALLOPIAN TUBE AND OVARY, RIGHT, SALPINGO-OOPHORECTOMY:
- BENIGN SEROUS CYSTADENOMA AND SEROUS CYSTADENOFIBROMA WITH FOCAL ATYPIA,
  SEE COMMENT.
- FALLOPIAN TUBE WITHIN NORMAL LIMITS.
- NEGATIVE FOR MALIGNANCY.

COMMENT:
A small focus of the sampled tissue has a focally complex architecture, compatible with a
borderline tumour; however, it represents less than 10% of the lesion. Thus, the lesion is
best classified as benign with focal atypia.

See also

References

  1. Feeley, KM.; Wells, M. (Feb 2001). "Precursor lesions of ovarian epithelial malignancy.". Histopathology 38 (2): 87-95. PMID 11207821.
  2. Okamoto, S.; Okamoto, A.; Nikaido, T.; Saito, M.; Takao, M.; Yanaihara, N.; Takakura, S.; Ochiai, K. et al. (May 2009). "Mesenchymal to epithelial transition in the human ovarian surface epithelium focusing on inclusion cysts.". Oncol Rep 21 (5): 1209-14. PMID 19360296.
  3. Okada, S.; Ohaki, Y.; Inoue, K.; Kawamura, T.; Hayashi, T.; Kato, T.; Kumazaki, T. (Feb 2005). "Calcifications in mucinous and serous cystic ovarian tumors.". J Nippon Med Sch 72 (1): 29-33. PMID 15834205.