Mantle cell lymphoma
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| Mantle cell lymphoma | |
|---|---|
| Diagnosis in short | |
 Mantle cell lymphoma. H&E stain. | |
|
| |
| LM | small monomorphic (uniform size, shape and staining) lymphoid population with abundant mitoses, +/-scattered epithelioid histiocytes (should not be confused with tingible-body macrophages), +/-sclerosed blood vessels |
| LM DDx | other small cell lymphomas (esp. MALT lymphoma), Burkitt lymphoma |
| IHC | cyclin D1 +ve, CD5 +ve, CD43 +ve, CD20 +ve, CD23 -ve |
| Molecular | t(11;14)(q13;q32) / IGH-CCND1 |
| Site | lymph node, GI tract, other sites |
|
| |
| Prevalence | not common |
| Prognosis | poor |
Mantle cell lymphoma, abbreviated MCL, is less common small cell lymphoma that is relatively aggressive when compared to other small cell lymphomas.
General
- Relatively aggressive - guarded prognosis.[1]
Microscopic
Features:[2]
- Small monomorphic (uniform size, shape and staining) lymphoid population.
- Abundant mitoses.
- Scattered epithelioid histiocytes (should not be confused with tingible-body macrophages).
- Sclerosed blood vessels.
DDx:
- Other small cell lymphomas, esp. marginal zone lymphoma.
- Burkitt's lymphoma.
Images
MCL - low mag. (WC)
MCL - intermed. mag. (WC)
MCL - low mag. - cyclin D1. (WC)
MCL - intermed. mag. - cyclin D1. (WC)
www:
IHC
Others:
- CD23 -ve.
- Positive in CLL.
Molecular
- t(11;14)(q13;q32) / IGH-CCND1.[5]
See also
References
- ↑ Hankin, RC.; Hunter, SV. (Dec 1999). "Mantle cell lymphoma.". Arch Pathol Lab Med 123 (12): 1182-8. doi:10.1043/0003-9985(1999)1231182:MCL2.0.CO;2. PMID 10583923.
- ↑ Good, D. 17 August 2010.
- ↑ URL: http://path.upmc.edu/cases/case308/dx.html. Accessed on: 14 January 2012.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 168461
- ↑ URL: http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html. Accessed on: 10 August 2010.