Osteoblastoma

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Osteoblastoma is benign primary bone tumour.

Osteoblastoma
Diagnosis in short

Osteoblastoma. H&E stain.

LM anastomosing bony trabeculae with variable mineralization, osteoblast rimming, no nuclear atypia of osteocytes
LM DDx osteoid osteoma, osteosarcoma
Clinical history usu. 15-20 years old, males > females
Symptoms +/-pain
Radiology > 1.5 cm (smaller lesions osteoid osteoma)
Clin. DDx osteosarcoma

General

  • Benign bone tumour.
  • Uncommon.[1]
  • Typically age 15-20 and male (male:female = ~2:1).[2]
  • Treatment: resection.[2]

Gross

  • Bone.
    • May be in the spine.[3]
  • Must be greater 1.5 cm by definition.[4]


Microscopic

Features:[5]

  • Anastomosing bony trabeculae with:
    • Osteoblasts rimming.
      • Cells line-up at edge of bone.

Notes:

Images

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BONE, LEFT FEMUR, EXCISION:
- OSTEOBLASTOMA.

See also

References

  1. Khan, IS.; Thakur, JD.; Chittiboina, P.; Nanda, A.. "Large sacral osteoblastoma: a case report and review of multi-disciplinary management strategies.". J La State Med Soc 164 (5): 251-5. PMID 23362588.
  2. 2.0 2.1 Villalobos, CE.; Rybak, LD.; Steiner, GC.; Wittig, JC. (2010). "Osteoblastoma of the sternum--case report and review of the literature.". Bull NYU Hosp Jt Dis 68 (1): 55-9. PMID 20345366.
  3. Boriani, S.; Amendola, L.; Bandiera, S.; Simoes, CE.; Alberghini, M.; Di Fiore, M.; Gasbarrini, A. (Oct 2012). "Staging and treatment of osteoblastoma in the mobile spine: a review of 51 cases.". Eur Spine J 21 (10): 2003-10. doi:10.1007/s00586-012-2395-8. PMID 22695702.
  4. 4.0 4.1 Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Oberman, Harold A; Reuter, Victor E (2004). Sternberg's Diagnostic Surgical Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 286. ISBN 978-0781740517.
  5. Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Oberman, Harold A; Reuter, Victor E (2004). Sternberg's Diagnostic Surgical Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 285. ISBN 978-0781740517.