Keratocystic odontogenic tumour

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Keratocystic odontogenic tumour, abbreviated KOT, is an uncommon odontogenic tumour.

Keratocystic odontogenic tumour
Diagnosis in short

Keratocystic odontogenic tumour. H&E stain.
LM DDx odontogenic cyst
Site usually mandible

Syndromes nevoid basal cell carcinoma syndrome

Clin. DDx ameloblastoma
Keratocystic odontogenic tumour
External resources

It was previously known as odontogenic keratocyst, abbreviated OKC.[1]

General

Clinical

Features:[2]

  • Most common presentation: swelling.

Gross

  • Location: usually mandible.
  • May mimic ameloblastoma radiologically.

Microscopic

Features: [3]

  • Stratified epithelium (resembling squamous epithelium) with:
    • "Ribbon-like appearance" - important.
      • Typically 8-10 cell layers thick - with relatively uniform thickness.
      • Lacks rete ridges.
    • Palisaded basal cell layer.
  • Parakeratosis (keratinized cells with nuclei) - key feature.
  • Artefactual separation of epithelium from the basement membrane.

DDx:

Images

www:

See also

References

  1. Madras, J.; Lapointe, H. (Mar 2008). "Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour.". J Can Dent Assoc 74 (2): 165-165h. PMID 18353202.
  2. Habibi, A.; Saghravanian, N.; Habibi, M.; Mellati, E.; Habibi, M. (Sep 2007). "Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population.". J Oral Sci 49 (3): 229-35. PMID 17928730.
  3. Thompson LDR. Head and neck pathology - (Foundations in diagnostic pathology). Goldblum JR, Ed.. Churchill Livingstone. 2006. ISBN 0-443-06960-3.
  4. Macdonald-Jankowski, DS. (Dec 2010). "Orthokeratinized odontogenic cyst: a systematic review.". Dentomaxillofac Radiol 39 (8): 455-67. doi:10.1259/dmfr/19728573.
  5. URL: http://www.sciencedirect.com/science/article/pii/S0968605305000992#fig5. Accessed on: 11 March 2013.