Hypertension

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Hypertension is very common and affects multiple organs. Clinically, it is usually classified as primary (idiopathic) and secondary.

Brain

Charcôt-Bouchard aneurysms

General

Microscopic

Features:[1]

  • Small aneurysms (~300 micrometers) with a fusiform shape.
  • Vessel wall changes:
    • Early:
      • Proliferation of arteriolar smooth muscle
    • Late:
      • Apoptotic smooth muscle cell death and collagen deposition.

Image: C-B aneurysm (ucsf.edu).

Eye

  • Blindness.

Heart

  • Concentric hypertrophy.

Kidney

General

  • May result in renal failure.

Microscopic

Features:[2]

  • Fibrinoid necrosis of afferent and interlobular arteries (due to endothelial cell damage).

See also

References

  1. ↑ Auer RN, Sutherland GR (December 2005). "Primary intracerebral hemorrhage: pathophysiology". Can J Neurol Sci 32 Suppl 2: S3–12. PMID 16450803.
  2. ↑ Ono H, Ono Y (November 1997). "Nephrosclerosis and hypertension". Med. Clin. North Am. 81 (6): 1273–88. PMID 9356598.

External links

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