Lung carcinoma with ALK rearrangement

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Lung carcinoma with ALK rearrangement is subset of lung adenocarcinoma.

General

  • Approximately 1-5% non-small cell lung carcinoma.[1]

Microscopic

Features:[1]

  • Adenocarcinoma - at least focally.
  • Solid signet-ring cell pattern - common.
  • Mucinous cribriform pattern - common.

DDx:

IHC

Features:[1]

  • p63 +ve.
  • TTF-1 +ve.

Molecular

  • EML4-ALK fusion -- inv(2)(p21p23).[2]

See also

References

  1. 1.0 1.1 1.2 Yoshida, A.; Tsuta, K.; Nakamura, H.; Kohno, T.; Takahashi, F.; Asamura, H.; Sekine, I.; Fukayama, M. et al. (Aug 2011). "Comprehensive histologic analysis of ALK-rearranged lung carcinomas.". Am J Surg Pathol 35 (8): 1226-34. doi:10.1097/PAS.0b013e3182233e06. PMID 21753699.
  2. Li, Y.; Ye, X.; Liu, J.; Zha, J.; Pei, L. (Jan 2011). "Evaluation of EML4-ALK fusion proteins in non-small cell lung cancer using small molecule inhibitors.". Neoplasia 13 (1): 1-11. PMID 21245935.