Serrated polyposis syndrome

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Hyperplastic polyposis syndrome is an uncommon condition characterized by the presence of (colonic) hyperplastic polyps, may represent several distinct pathologies and is associated with an increased risk of colorectal carcinoma.[1]

WHO definition

One of the following three:[1]

  1. >=Five hyperplastic polyps proximal to the sigmoid colon with two of the five >=10 mm.
  2. One hyperplastic polyps proximal to the sigmoid colon, in someone with a first degree relative with the syndrome.
  3. >30 hyperplastic polyps through-out the colon, i.e. not all can be rectal polyps.
    • One source[2] suggests it ought to be >=20 HPs.

References

  1. 1.0 1.1 Huang, CS.; Farraye, FA.; Yang, S.; O'Brien, MJ. (Feb 2011). "The clinical significance of serrated polyps.". Am J Gastroenterol 106 (2): 229-40; quiz 241. doi:10.1038/ajg.2010.429. PMID 21045813.
  2. URL: http://www.hindawi.com/journals/pri/2011/157073/. Accessed on: 13 December 2011.