Traumatic ulcerative granuloma with stromal eosinophilia

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Traumatic ulcerative granuloma with stromal eosinophilia, abbreviated TUGSE, is a benign lesion of the oral mucosa.[1]

Traumatic ulcerative granuloma with stromal eosinophilia
Diagnosis in short

TUGSE. H&E stain. (WC/Nephron)
LM stromal eosinophils and lymphocytes, ulceration.
LM DDx diffuse large B-cell lymphoma, lobular capillary hemangioma (pyogenic granuloma), granulation tissue
Site head and neck - usually tongue
Prevalence uncommon
Prognosis benign

It is also known as traumatic ulcerative granuloma with stromal eosinphils, eosinophilic ulcer of tongue and traumatic eosinophilic granuloma.

General

  • Benign.
  • Obscure lesion that is not widely known.[2]

Gross

  • Usually tongue ~ 2/3 of cases.[3]

Microscopic

Features:[2]

  • Stromal eosinophils and lymphocytes.
  • Ulceration.

DDx:

Images

  • TUGSE - extremely low mag. (WC)

  • TUGSE - very low mag. (WC)

  • TUGSE - low mag. (WC)

  • TUGSE - intermed. mag. (WC)

  • TUGSE - intermed. mag. (WC)

  • TUGSE - high mag. (WC)

  • TUGSE - high mag. (WC)

  • TUGSE - very high mag. (WC)

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Lesion, Right Tongue, Excisional Biopsy:
     - Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE), see comment.
     - NEGATIVE for malignancy.

Comment:
TUGSE is an uncommon benign lesion of the oral mucosa.

See also

References

  1. ↑ Hirshberg, A.; Amariglio, N.; Akrish, S.; Yahalom, R.; Rosenbaum, H.; Okon, E.; Kaplan, I. (Oct 2006). "Traumatic ulcerative granuloma with stromal eosinophilia: a reactive lesion of the oral mucosa.". Am J Clin Pathol 126 (4): 522-9. doi:10.1309/AFHA406GBT0N2Y64. PMID 16938660.
  2. ↑ 2.0 2.1 Sarangarajan, R.; Vaishnavi Vedam, VK.; Sivadas, G.; Sarangarajan, A.; Meera, S. (Aug 2015). "Traumatic ulcerative granuloma with stromal eosinophilia - Mystery of pathogenesis revisited.". J Pharm Bioallied Sci 7 (Suppl 2): S420-3. doi:10.4103/0975-7406.163474. PMID 26538890.
  3. ↑ Shen, WR.; Chang, JY.; Wu, YC.; Cheng, SJ.; Chen, HM.; Wang, YP. (Sep 2015). "Oral traumatic ulcerative granuloma with stromal eosinophilia: A clinicopathological study of 34 cases.". J Formos Med Assoc 114 (9): 881-5. doi:10.1016/j.jfma.2013.09.012. PMID 24269143.
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