Difference between revisions of "Neuropathology"

Neuropathology (view source)

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 ===Normal cells===
 *Neuron:
-**Very large cells, with angled edges.
+**Abundant cytoplasm - '''key feature'''.
-**Abundant cytoplasm.
+**Often very large cells, with angled edges.
 **Prominent nucleolus.
+**Nissl substance (granular perinuclear material - rough ER).
 *Glial cells.
-**Oligodendrocyte - small dense nuclei (lymphocyte-like nucleus).
+**Oligodendrocyte.
+***Small round nuclei (lymphocyte-like nucleus) - '''key feature'''.
 ***May resemble a ''fried egg'' on H&E (clear cytoplasm, central nucleus).
-*Astrocyte.
+**Astrocyte.
-**Eosinophilic cytoplasm.
+***Irregular non-ovoid nucleus - '''key feature'''.
-**Nuclei less dense than in oligodendrocyte.
+****Image: [http://embryology.med.unsw.edu.au/histology/endocrine/pin42he.jpg astrocyte (med.unsw.edu.au)] (in [http://embryology.med.unsw.edu.au/notes/endocrine12.htm endocrine development]).
-**Close to blood vessels.
+***Nuclei less dense than in oligodendrocyte.
-**Have processes.
+***Close to blood vessels.
-**Form blood-brain barrier.
+***Form blood-brain barrier.
-*Microglia - macrophage of the brain (derived from monocyte).
+***Cytoplasm normally ''not'' visible.
-**May be large.
+**Microglia - macrophage of the brain (derived from monocyte).
-**May have vesicles.
+***May be large.
+***May have vesicles.
 *Ependyma.
 **Simple ciliated cuboidal epithelium.