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Difference between revisions of "Hypersensitivity"
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==Gell & Goombs classification== | ==Gell & Goombs classification== | ||
{|Class="wikitable" | {|Class="wikitable" | ||
! Type (I-IV) | ! Type (I-IV) | ||
! Formal name<ref>{{Ref PCPBoD8|110}}</ref> | |||
! Name | ! Name | ||
! Example | ! Example | ||
! | ! Mediator | ||
! Pathology | |||
|- | |- | ||
| I | | I | ||
| | | Immediate h. | ||
| | | Allergic h. | ||
| | | [[anaphylaxis]], (atopic) bronchial [[asthma]], allergies | ||
| IgE | |||
| mast cells, inflammation (esp. eosinophils), edema | |||
|- | |- | ||
| II | | II | ||
| Cytotoxic antibody dependent | | Antibody mediated h. | ||
| | | Cytotoxic antibody dependent h. | ||
| | | [[Goodpasture syndrome]] | ||
| antibodies (IgG, IgM) | |||
| (antibody-mediated) phagocytosis & lysis | |||
|- | |- | ||
| III | | III | ||
| Immune complex | | Immune complex mediated h. | ||
| | | Immune complex mediated h. | ||
| | | [[systemic lupus erythematosus]] | ||
| antigen-antibody complex | |||
| inflammation, [[vasculitis]] with [[fibrinoid necrosis]] | |||
|- | |- | ||
| IV | | IV | ||
| Cell-mediated h. | |||
| Delayed-type hypersensitivity | | Delayed-type hypersensitivity | ||
| | | tuberculosis | ||
| | | activated T cells | ||
| perivascular inflammation, [[granuloma]]s | |||
|} | |} | ||
Memory device ''ACID'':<ref>URL: [http://www.saintcyr.com/2001/mnemonic.html http://www.saintcyr.com/2001/mnemonic.html]. Accessed on: 13 November 2011.</ref> | |||
*Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity. | |||
==See also== | ==See also== | ||
*[[Hypersensitivity pneumonitis]]. | *[[Hypersensitivity pneumonitis]]. | ||