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Difference between revisions of "Kidney tumours"
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Notes: | Notes: | ||
*Cell shape: all have epithelioid morphology. | *Cell shape: all have epithelioid morphology. | ||
Histomorphologic features useful to distinguish ChRCC and oncocytoma:<ref name=pmid9844591>{{Cite journal | last1 = Tickoo | first1 = SK. | last2 = Amin | first2 = MB. | title = Discriminant nuclear features of renal oncocytoma and chromophobe renal cell carcinoma. Analysis of their potential utility in the differential diagnosis. | journal = Am J Clin Pathol | volume = 110 | issue = 6 | pages = 782-7 | month = Dec | year = 1998 | doi = | PMID = 9844591 }} | |||
</ref> | |||
{| class="wikitable" | |||
| | |||
| ChRCC | |||
| Oncocytoma | |||
|- | |||
| Nuclear morphology | |||
| "raisinoid"/wrinkled | |||
| round with small nucleolus, little size variation | |||
|- | |||
| Multinucleation | |||
| common - binucleation | |||
| uncommon | |||
|- | |||
| Chromatin | |||
| coarse | |||
| fine | |||
|- | |||
| Architecture | |||
| solid, crowded nests | |||
| spaced nests / archipelago-like, solid | |||
|- | |||
| Cytoplasm | |||
| perinuclear halo, may be focal | |||
| no halo | |||
|- | |||
| Degenerative foci<br>(focal atypia & pleomorphism) | |||
| absent | |||
| present in ~20% of cases | |||
|} | |||
==Hereditary RCC== | ==Hereditary RCC== | ||