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Difference between revisions of "Kidney tumours"
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→Renal translocation carcinomas: more
(→Renal translocation carcinomas: more) |
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*Extensive aneusomy (monosomy?):<ref name=Ref_WMSP292>{{Ref WMSP|292}}</ref> | *Extensive aneusomy (monosomy?):<ref name=Ref_WMSP292>{{Ref WMSP|292}}</ref> | ||
**Loss of chromosomes: 1, 2, 6, 10, 13, 17, 21. | **Loss of chromosomes: 1, 2, 6, 10, 13, 17, 21. | ||
==Clear cell papillary renal cell carcinoma== | |||
*[[AKA]] ''clear cell tubulopapillary renal cell carcinoma''.<ref name=pmid21602815>{{Cite journal | last1 = Rohan | first1 = SM. | last2 = Xiao | first2 = Y. | last3 = Liang | first3 = Y. | last4 = Dudas | first4 = ME. | last5 = Al-Ahmadie | first5 = HA. | last6 = Fine | first6 = SW. | last7 = Gopalan | first7 = A. | last8 = Reuter | first8 = VE. | last9 = Rosenblum | first9 = MK. | title = Clear-cell papillary renal cell carcinoma: molecular and immunohistochemical analysis with emphasis on the von Hippel-Lindau gene and hypoxia-inducible factor pathway-related proteins. | journal = Mod Pathol | volume = 24 | issue = 9 | pages = 1207-20 | month = Sep | year = 2011 | doi = 10.1038/modpathol.2011.80 | PMID = 21602815 }}</ref> | |||
===General=== | |||
*New entity not in the WHO classification. | |||
===Microscopic=== | |||
Features:<ref name=pmid21602815/> | |||
*Features of both: | |||
*#Clear cell RCC. | |||
*#Papillary RCC. | |||
*#*Often do not have true papillae. | |||
DDx: | |||
*[[Papillary renal cell carcinoma]]. | |||
*[[Clear cell renal cell carcinoma]] | |||
*[[Xp11.2 translocation carcinoma]]. | |||
===IHC=== | |||
Features:<ref name=pmid21602815/> | |||
*CK7 +ve. | |||
**Usu. -ve in CRCC. | |||
*CD10 -ve. | |||
**Usu. +ve in RCC. | |||
*TFE3 -ve. | |||
**By definition +ve in [[Xp11.2 translocation carcinoma]]. | |||
*AMACR -ve. | |||
**Usu. +ve in PaRCC. | |||
Others:<ref name=pmid21602815/> | |||
*HIF-1alpha +ve. | |||
*GLUT-1 +ve. | |||
=Renal translocation carcinomas= | =Renal translocation carcinomas= | ||