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[[Image:Confluent_epidermal_necrosis_-_very_high_mag.jpg|thumb|right|250px|Confluent epidermal necrosis. [[H&E stain]].]] | |||
'''Epidermal necrosis''' is an important finding in [[dermatopathology]]. Full-thickness necrosis, especially is very serious. | '''Epidermal necrosis''' is an important finding in [[dermatopathology]]. Full-thickness necrosis, especially is very serious. | ||
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**These are signed-out as "confluent epidermal necrosis - see comment". | **These are signed-out as "confluent epidermal necrosis - see comment". | ||
***Comment: The histomorphologic findings are consistent with EM/SJS/TEN. | ***Comment: The histomorphologic findings are consistent with EM/SJS/TEN. | ||
**The clinical DDx of EM/SJS/TEN includes ''acute generalized exanthematous pustulosis'' (AGEP). | **The clinical DDx of EM/SJS/TEN includes ''[[acute generalized exanthematous pustulosis]]'' (AGEP). | ||
==Erythema multiforme== | ==Erythema multiforme== | ||
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===General=== | ===General=== | ||
Features:<ref name=Ref_PBoD8_1189>{{Ref PBoD8|1189}}</ref> | Features:<ref name=Ref_PBoD8_1189>{{Ref PBoD8|1189}}</ref> | ||
*Hypersensitivity disorder due to a drug ''or'' infection. | *[[Hypersensitivity]] disorder due to a drug ''or'' infection. | ||
**Associated with the following: [[HSV]], Mycoplasma, [[Histoplasma]], others. | **Associated with the following: [[HSV]], Mycoplasma, [[Histoplasma]], others. | ||
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*+/-Epidermal sloughing. | *+/-Epidermal sloughing. | ||
Images | ====Images==== | ||
<gallery> | |||
Image: Confluent epidermal necrosis - low mag.jpg | Confluent epidermal necrosis - low mag. (WC) | |||
Image: Confluent epidermal necrosis - intermed mag.jpg | Confluent epidermal necrosis - intermed. mag. (WC) | |||
Image: Confluent epidermal necrosis - high mag.jpg | Confluent epidermal necrosis - high mag. (WC) | |||
Image: Confluent epidermal necrosis - very high mag.jpg | Confluent epidermal necrosis - very high mag. (WC) | |||
</gallery> | |||
==Stevens-Johnson syndrome== | ==Stevens-Johnson syndrome== | ||
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===General=== | ===General=== | ||
Rx causes of SJS: | Rx causes of SJS: | ||
* | *[[NSAID]]s. | ||
*Anticonvulsants. | *Anticonvulsants. | ||
*Sulfonamides. | *Sulfonamides. | ||
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Features: | Features: | ||
*Similar [[erythema multiforme]]. | *Similar [[erythema multiforme]]. | ||
====Images==== | |||
<gallery> | |||
Image: Confluent epidermal necrosis - low mag.jpg | Confluent epidermal necrosis - low mag. (WC) | |||
Image: Confluent epidermal necrosis - intermed mag.jpg | Confluent epidermal necrosis - intermed. mag. (WC) | |||
Image: Confluent epidermal necrosis - high mag.jpg | Confluent epidermal necrosis - high mag. (WC) | |||
Image: Confluent epidermal necrosis - very high mag.jpg | Confluent epidermal necrosis - very high mag. (WC) | |||
</gallery> | |||
==Toxic epidermal necrolysis== | ==Toxic epidermal necrolysis== | ||
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Features: | Features: | ||
*Like [[erythema multiforme]] - but usu. less inflammation.<ref>S. Sade. 8 September 2011.</ref> | *Like [[erythema multiforme]] - but usu. less inflammation.<ref>S. Sade. 8 September 2011.</ref> | ||
====Images==== | |||
<gallery> | |||
Image: Confluent epidermal necrosis - low mag.jpg | Confluent epidermal necrosis - low mag. (WC) | |||
Image: Confluent epidermal necrosis - intermed mag.jpg | Confluent epidermal necrosis - intermed. mag. (WC) | |||
Image: Confluent epidermal necrosis - high mag.jpg | Confluent epidermal necrosis - high mag. (WC) | |||
Image: Confluent epidermal necrosis - very high mag.jpg | Confluent epidermal necrosis - very high mag. (WC) | |||
</gallery> | |||
==Staphylococcal scalded skin syndrome== | ==Staphylococcal scalded skin syndrome== | ||