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Difference between revisions of "Kidney tumours"
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→Papillary renal cell carcinoma
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*May be abbreviated ''PRCC''. | *May be abbreviated ''PRCC''. | ||
===Epidemiology=== | ====Epidemiology==== | ||
*Associated with '' | *Associated with ''[[acquired renal cystic disease]]''.<ref>{{Ref DARP|438}}</ref> | ||
*May be familial. | |||
===Microsopic=== | ===Microsopic=== | ||
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*Papillary lesions '''''must''''' be >0.5 cm to be called ''carcinoma''; smaller lesions (<=0.5 cm) are called ''papillary adenomas''.<ref name=Ref_GUP288>{{Ref GUP|288}}</ref> | *Papillary lesions '''''must''''' be >0.5 cm to be called ''carcinoma''; smaller lesions (<=0.5 cm) are called ''papillary adenomas''.<ref name=Ref_GUP288>{{Ref GUP|288}}</ref> | ||
Histological subtyping:<ref name=Ref_GUP289>{{Ref GUP|289}}</ref> | Clear cell RCC vs. papillary RCC: | ||
*Papillary: +histiocytes, +intracellular hemosiderin, [[CK7]]+. | |||
====Histological subtyping==== | |||
Subtypes:<ref name=Ref_GUP289>{{Ref GUP|289}}</ref> | |||
*''Type 1'' - single layer of cells on basement membrane. | *''Type 1'' - single layer of cells on basement membrane. | ||
** usually low grade nuclear features, i.e. low Fuhrman grade. | ** usually low grade nuclear features, i.e. low Fuhrman grade. | ||
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*[http://www.e-immunohistochemistry.info/web/Papillary_renal_cell_carcinoma.htm e-immunohistochemistry.info] | *[http://www.e-immunohistochemistry.info/web/Papillary_renal_cell_carcinoma.htm e-immunohistochemistry.info] | ||
=== | ===Molecular=== | ||
* | Features:<ref name=Ref_PBoD1016>{{Ref PBoD|1016}}</ref> | ||
*Sporadic: trisomies 7, 16, 17. | |||
*Familial: trisomy 7. | |||
**Chromosome 7 = location of MET gene. | |||
Note: | |||
*Not used for diagnosis.<ref>{{Ref WMSP|292}}</ref> | |||
==Chromophobe renal cell carcinoma== | ==Chromophobe renal cell carcinoma== | ||