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Difference between revisions of "Basics"
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→Basic pathologic DDx of malignancy
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§ mitoses are seen in poorly differentiated tumour and regeneration. High mitotic rate in the context of unremarkable nuclear morphology is usually not malignant. | § mitoses are seen in poorly differentiated tumour and regeneration. High mitotic rate in the context of unremarkable nuclear morphology is usually not malignant. | ||
===Basic pathologic | ===Basic pathologic differential diagnosis of malignancy=== | ||
This should ''always'' be considered: | |||
<center> | <center> | ||
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</center> | </center> | ||
Q. Why? <br> | Q. Why? <br> | ||
A. The site of the tumour can considerably change the differential diagnosis. <br><br> | A. (1) The site of the tumour can considerably change the differential diagnosis. (2) The management is usually totally different.<br><br> | ||
A clinically motivated histomorphologic classification of malignancy: | |||
<center> | <center> | ||
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{{familytree | | | | | | | | | | | A | | | | | | | | | | |A=Malignancy}} | {{familytree | | | | | | | | | | | A | | | | | | | | | | |A=Malignancy}} | ||
{{familytree | |,|-|-|-|v|-|-|-|v|-|^|-|v|-|-|-|v|-|-|-|.| |}} | {{familytree | |,|-|-|-|v|-|-|-|v|-|^|-|v|-|-|-|v|-|-|-|.| |}} | ||
{{familytree | B | | C | | D | | E | | F | |G |B=Epithelial<br>(Carcinoma)|C=Mesenchymal<br>(Sarcoma)|D=Germ cell<br>tumour|E=Neuroendocrine<br>carcinoma|F= | {{familytree | B | | C | | D | | E | | F | |G |B=Epithelial<br>(Carcinoma)|C=Mesenchymal<br>(Sarcoma)|D=Germ cell<br>tumour|E=Neuroendocrine<br>carcinoma|F=Hematologic|G=Malignant<br>melanoma}} | ||
{{familytree/end}} | {{familytree/end}} | ||
</center> | </center> | ||
Notes: | Notes: | ||
*'' | *''[[Malignant melanoma]]'', also ''melanoma'', is a separate category as it can look like almost anything under the microscope. | ||
*''[[ | *''Hematologic'' includes [[lymphoma]], [[leukemia]], [[plasma cell neoplasms]] and others. | ||
===Morphologic grouping=== | ===Morphologic grouping=== | ||