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Difference between revisions of "Ovarian tumours"
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→Transitional cell carcinoma: more
m (→Surface epithelial tumours: w) |
(→Transitional cell carcinoma: more) |
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features:<ref name=pmid15087664>{{Cite journal | last1 = Eichhorn | first1 = JH. | last2 = Young | first2 = RH. | title = Transitional cell carcinoma of the ovary: a morphologic study of 100 cases with emphasis on differential diagnosis. | journal = Am J Surg Pathol | volume = 28 | issue = 4 | pages = 453-63 | month = Apr | year = 2004 | doi = | PMID = 15087664 }}</ref> | ||
* | *Cystic spaces: | ||
** | **Small - punched-out border - very common. | ||
**Large. | |||
*Papillae, usu. large, blunt. | |||
**Occasionally small and filiform. | |||
*+/-Bizarre giant cells (35%) | |||
*+/-Gland-like tubules. | |||
*+/-Squamous differentiation. | |||
*+/-[[Psammoma bodies]]. | |||
*Cells: | |||
**Moderate basophilic cytoplasm and little intervening stroma. | |||
**Marked nuclear pleomorphism. | **Marked nuclear pleomorphism. | ||
**Mitoses - common. | **Mitoses - common. | ||
Notes: | |||
#Resembles [[urothelial carcinoma]].<ref name=pmid21073751>{{Cite journal | last1 = Tazi | first1 = EM. | last2 = Lalya | first2 = I. | last3 = Tazi | first3 = MF. | last4 = Ahellal | first4 = Y. | last5 = M'rabti | first5 = H. | last6 = Errihani | first6 = H. | title = Transitional cell carcinoma of the ovary: a rare case and review of literature. | journal = World J Surg Oncol | volume = 8 | issue = | pages = 98 | month = | year = 2010 | doi = 10.1186/1477-7819-8-98 | PMID = 21073751 }}</ref> | |||
#'''No''' Brenner tumor component (benign or malignant) should be present.<ref name=pmid21073751/> | |||
===IHC=== | |||
Features:<ref name=pmid21073751>{{Cite journal | last1 = Tazi | first1 = EM. | last2 = Lalya | first2 = I. | last3 = Tazi | first3 = MF. | last4 = Ahellal | first4 = Y. | last5 = M'rabti | first5 = H. | last6 = Errihani | first6 = H. | title = Transitional cell carcinoma of the ovary: a rare case and review of literature. | journal = World J Surg Oncol | volume = 8 | issue = | pages = 98 | month = | year = 2010 | doi = 10.1186/1477-7819-8-98 | PMID = 21073751 }}</ref> | |||
#Vimentin +ve, | |||
#CA-125 +ve. | |||
#WT1 +ve. | |||
#CK20 -ve. | |||
#Thrombomodulin -ve. | |||
#Uroplakin III -ve. | |||
Notes: | |||
*1-6 usu. opposite pattern in urothelial cell carcinoma. | |||
==Brenner tumour== | ==Brenner tumour== | ||