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Difference between revisions of "Kidney tumours"
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→Clear cell carcinoma: format
m (→Fuhrman grading in short: format) |
m (→Clear cell carcinoma: format) |
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*+/-Necrosis (common in large tumours). | *+/-Necrosis (common in large tumours). | ||
=== | ===Microscopic=== | ||
*Clear cells | Features:<ref>PBoD P.1017-8</ref> | ||
*Solid or trabecular pattern | *Clear cells. | ||
*Solid or trabecular pattern. | |||
*Delicate branching vasculature. | *Delicate branching vasculature. | ||
*Hyaline bodies common<ref>AFIP Renal Tumours Book.</ref> | *Hyaline bodies common.<ref>AFIP Renal Tumours Book.</ref> | ||
**Not common in papillary RCC. | **Not common in papillary RCC. | ||
===IHC=== | ===IHC=== | ||
*CK7- | *CK7 -ve. | ||
*CK20- | *CK20 -ve. | ||
*Hale's colloidal iron- | *Hale's colloidal iron -ve. | ||
**+ve in chromophobe | **+ve in chromophobe. | ||
Note: ''[[Hale's colloidal iron]]'' does not stain iron... it stains hemosiderin.<ref>Latta Jan 27, '09</ref> | Note: ''[[Hale's colloidal iron]]'' does not stain iron... it stains hemosiderin.<ref>Latta Jan 27, '09</ref> | ||
Clear cell vs. chromophobe | Clear cell vs. chromophobe: | ||
* | *Chromophobe: "translucent" (NOT quite clear), reticulated, +Hale's colloidal iron stain, CK7+ (cell membrane). | ||
Clear cell vs. [[adrenocortical carcinoma]] | Clear cell vs. [[adrenocortical carcinoma]]: | ||
*ACC: EMA- (epithelial membrane antigen), cytokeratin mostly neg., inhibin+ (neg. in RCC).<ref>GUP P.285.</ref> | *ACC: EMA- (epithelial membrane antigen), cytokeratin mostly neg., inhibin+ (neg. in RCC).<ref>GUP P.285.</ref> | ||