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(→Small cell lung carcinoma: format) |
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| Weak discriminative valuable | | Weak discriminative valuable | ||
|- | |- | ||
| Large nucleoli | | Large [[nucleoli]] | ||
| '''Never''' | | '''Never''' | ||
| '''Present''' | | '''Present''' | ||
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#*Good ones are visible with 10X objective (excludes SCLC). | #*Good ones are visible with 10X objective (excludes SCLC). | ||
#*Look for subtle large ones - at higher power. | #*Look for subtle large ones - at higher power. | ||
#*Neuroendocrine tumours occasionally may appear to have nucleoli - one should see good nucleoli in 3-4 cells in one field. | #*Neuroendocrine tumours occasionally may appear to have [[nucleoli]] - one should see good nucleoli in 3-4 cells in one field. | ||
#'''Abundant cytoplasm''' - virtually excludes small cell carcinoma. | #'''Abundant cytoplasm''' - virtually excludes small cell carcinoma. | ||
#Vacuoles with mucin (pink discolouration) - virtually diagnostic, though only seen occasionally. | #Vacuoles with mucin (pink discolouration) - virtually diagnostic, though only seen occasionally. | ||
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#Mixure of epithelioid cells and spindle cells. | #Mixure of epithelioid cells and spindle cells. | ||
#Malignant cells have: | #Malignant cells have: | ||
#*Prominent red nucleolus. | #*Prominent [[red nucleolus]]. | ||
#*Pigmented cytoplasm - '''key feature''' (often not pigmented). | #*Pigmented cytoplasm - '''key feature''' (often not pigmented). | ||
#*Pigment may only be present in macrophages | #*Pigment may only be present in macrophages |
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