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Difference between revisions of "Neuropathology tumours"
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→Dysembryoplastic neuroepithelial tumour: +SEGA
m (→Medulloblastoma: primitive neuroepithelial tumour --> primitive neuroectodermal tumour) |
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| Line 327: | Line 327: | ||
*[[Oligodendroglioma]]. | *[[Oligodendroglioma]]. | ||
**These have rounder, smaller nuclei with occasional nucleoli.<ref name=pmid18071981/> | **These have rounder, smaller nuclei with occasional nucleoli.<ref name=pmid18071981/> | ||
==Subependymal giant cell astrocytoma== | |||
*Abbreviated ''SEGA''. | |||
===General=== | |||
Associated with [[TSC]].<ref name=pmid21455842>{{Cite journal | last1 = Grajkowska | first1 = W. | last2 = Kotulska | first2 = K. | last3 = Jurkiewicz | first3 = E. | last4 = Roszkowski | first4 = M. | last5 = Daszkiewicz | first5 = P. | last6 = Jóźwiak | first6 = S. | last7 = Matyja | first7 = E. | title = Subependymal giant cell astrocytomas with atypical histological features mimicking malignant gliomas. | journal = Folia Neuropathol | volume = 49 | issue = 1 | pages = 39-46 | month = | year = 2011 | doi = | PMID = 21455842 }}</ref> | |||
*WHO Grade I. | |||
===Microscopic=== | |||
Features:<ref name=upmc_case179/><ref name=pmid9595853>{{Cite journal | last1 = Taraszewska | first1 = A. | last2 = Kroh | first2 = H. | last3 = Majchrowski | first3 = A. | title = Subependymal giant cell astrocytoma: clinical, histologic and immunohistochemical characteristic of 3 cases. | journal = Folia Neuropathol | volume = 35 | issue = 3 | pages = 181-6 | month = | year = 1997 | doi = | PMID = 9595853 }}</ref> | |||
*Giant cells with nuclear atypia ("bizarre cells"). | |||
**Vesicular nuclei. | |||
*Glassy eosinophilic cytoplasm. | |||
Image: | |||
*[http://path.upmc.edu/cases/case179/images/micro5.jpg SEGA (upmc.edu)].<ref name=upmc_case179>URL: [http://path.upmc.edu/cases/case179.html http://path.upmc.edu/cases/case179.html]. Accessed on: 29 July 2011.</ref> | |||
===IHC=== | |||
Features:<ref name=pmid9595853/> | |||
*GFAP +ve. (???) | |||
*Vimentin +ve. (???) | |||
*S100 +ve. (???) | |||
==Pilomyxoid astrocytoma== | ==Pilomyxoid astrocytoma== | ||