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Difference between revisions of "Ovarian tumours"
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→Clear cell adenocarcinoma: micrographs - links
(→Microscopic: more) |
(→Clear cell adenocarcinoma: micrographs - links) |
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==Clear cell adenocarcinoma== | ==Clear cell adenocarcinoma== | ||
*[[AKA]] clear cell carcinoma. | |||
===General=== | ===General=== | ||
* Thought to be related to endometrioid carcinoma.<ref name=Ref_PBoD1098>{{Ref PBoD |1098}}</ref> | * Thought to be related to endometrioid carcinoma.<ref name=Ref_PBoD1098>{{Ref PBoD |1098}}</ref> | ||
| Line 235: | Line 236: | ||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Cystic/tubular architecture. | *Cystic/tubular architecture - important low power feature. | ||
*[[Hobnail morphology]] - apical surface larger than basal surface.<ref>URL: [http://www.pathologyoutlines.com/ovary.html http://www.pathologyoutlines.com/ovary.html]. Accessed on: 8 February 2011.</ref> | *Clear cells - cytoplasm is clear - '''key feature'''. | ||
*[[Hobnail morphology]] - apical surface larger than basal surface.<ref>URL: [http://www.pathologyoutlines.com/ovary.html http://www.pathologyoutlines.com/ovary.html]. Accessed on: 8 February 2011.</ref> | |||
**"Nuclei bulge into the lumen". | **"Nuclei bulge into the lumen". | ||
*Hyaline droplets -- common, as in ''clear cell [[renal cell carcinoma]]''. | *Hyaline droplets -- common, as in ''clear cell [[renal cell carcinoma]]''. | ||
**Eosinophilic bodies within lumen. | **Eosinophilic bodies within lumen. | ||
*Nucleoli - prominent. | *Nucleoli - prominent. | ||
Note: | Note: | ||
*Clear cell adenocarcinoma does not have to have clear cells... yes, this is stupid; it is like ''papillary thyroid carcinoma'' -- which often isn't papillary. | *Clear cell adenocarcinoma does not have to have clear cells... yes, this is stupid; it is like ''papillary thyroid carcinoma'' -- which often isn't papillary. | ||
**The ''hobnail morphology'' is important if this is the case. | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Ovarian_clear_cell_carcinoma_-a-_very_high_mag_-_cropped.jpg Clear cell carcinoma - very high mag. - cropped (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Ovarian_clear_cell_carcinoma_-a-_intermed_mag.jpg Clear cell carcinoma - intermed. mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Ovarian_clear_cell_carcinoma_-_low_mag.jpg Clear cell carcinoma - low mag. (WC)]. | |||
===IHC=== | ===IHC=== | ||