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Difference between revisions of "ABCC2"
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*Brush border staining suggests response to immunotherapy.<ref>{{cite journal |authors=Castillo VF, Zakhary A, Rotondo F, Di Ciano-Oliveira C, Hamdani M, Adona E, van der Kwast T, Trpkov K, Saleeb R |title=Papillary renal cell carcinoma with high-ABCC2 shows an immune-evasive profile associated with favorable response to immunotherapy |journal=J Pathol |volume=268 |issue=2 |pages=188–199 |date=February 2026 |pmid=41259021 |doi=10.1002/path.70001 |url=}}</ref> | *Brush border staining suggests response to immunotherapy.<ref>{{cite journal |authors=Castillo VF, Zakhary A, Rotondo F, Di Ciano-Oliveira C, Hamdani M, Adona E, van der Kwast T, Trpkov K, Saleeb R |title=Papillary renal cell carcinoma with high-ABCC2 shows an immune-evasive profile associated with favorable response to immunotherapy |journal=J Pathol |volume=268 |issue=2 |pages=188–199 |date=February 2026 |pmid=41259021 |doi=10.1002/path.70001 |url=}}</ref> | ||
==Sign out== | |||
===Positive=== | |||
<pre> | |||
ABCC2 brush border staining in the tumour is PRESENT, patchy and estimated as >50%; the presence of significant ABCC2 staining suggests a more aggressive disease.[1] | |||
The findings are in keeping with papillary renal cell carcinoma; the diagnosis is not changed. | |||
1. Histopathology. 2023 Dec;83(6):949-958. doi: 10.1111/his.15042. | |||
</rep> | |||
===Negative=== | |||
<pre> | |||
Significant ABCC2 brush border staining in the tumour is ABSENT (<50%). | |||
</pre> | |||
==References== | ==References== | ||