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Difference between revisions of "Molecular pathology"
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→Overview
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! Other | ! Other | ||
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| ISH break apart probe | | ISH break apart probe (two colours) | ||
| probes label two parts of a (normal) gene; the two markers straddle (common) break points | | probes label two parts of a (normal) gene; the two markers straddle (common) break points | ||
| gene fragmentation consistent with translocation; one may find: loss of part of the gene, gene duplication | | gene fragmentation consistent with translocation; one may find: loss of part of the gene, gene duplication | ||
| Line 67: | Line 67: | ||
| can detect translocations - without knowing the specific fusion product | | can detect translocations - without knowing the specific fusion product | ||
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| ISH fusion probe | | ISH fusion probe (two colours) | ||
| probes label different genes (that are not adjacent) | | probes label different genes (that are not adjacent) | ||
| translocation involving the two genes labeled; one may find: gene duplication, loss of a gene) | | translocation involving the two genes labeled; one may find: gene duplication, loss of a gene) | ||
| Line 73: | Line 73: | ||
| can detect one specific translocation | | can detect one specific translocation | ||
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| ISH one colour | | ISH probe (one colour) | ||
| probe label one region (gene) | | probe label one region (gene) | ||
| gene duplication, loss of a gene | | gene duplication, loss of a gene | ||
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