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Difference between revisions of "Biphasic hyalinizing psammomatous renal cell carcinoma"
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Biphasic hyalinizing psammomatous renal cell carcinoma (view source)
Revision as of 17:56, 25 March 2024
, 25 Marchno edit summary
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{{ Infobox diagnosis | |||
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| Micro = biphasic cytomorphology (small cells and large cells), hyaline stroma, [[psammoma bodies]] | |||
| Subtypes = | |||
| LMDDx = [[TFEB renal cell carcinoma]], [[papillary renal cell carcinoma]], [[FH-deficient renal cell carcinoma]] | |||
| Stains = | |||
| IHC = merlin loss of staining, [[HNF-1beta]] +ve, [[PAX8]] +ve, [[CK7]] +ve, EMA +ve, AMACR +ve, WT1 -ve, Melan A -ve, HMB-45 -ve, [[GATA3]] -ve | |||
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| Molecular = neurofibromin 2 mutations | |||
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}} | |||
'''Biphasic hyalinizing psammomatous renal cell carcinoma''', abbreviated '''BHP RCC''', is a rare type of [[renal cell carcinoma]] with mutations in neurofibromin 2.<ref name=pmid32217839>{{cite journal |authors=Argani P, Reuter VE, Eble JN, Vlatkovic L, Yaskiv O, Swanson D, Dickson BC, Antonescu CR, Matoso A, Gagan J, Palsgrove DN |title=Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma (BHP RCC): A Distinctive Neoplasm Associated With Somatic NF2 Mutations |journal=Am J Surg Pathol |volume=44 |issue=7 |pages=901–916 |date=July 2020 |pmid=32217839 |pmc=7350624 |doi=10.1097/PAS.0000000000001467 |url=}}</ref> | '''Biphasic hyalinizing psammomatous renal cell carcinoma''', abbreviated '''BHP RCC''', is a rare type of [[renal cell carcinoma]] with mutations in neurofibromin 2.<ref name=pmid32217839>{{cite journal |authors=Argani P, Reuter VE, Eble JN, Vlatkovic L, Yaskiv O, Swanson D, Dickson BC, Antonescu CR, Matoso A, Gagan J, Palsgrove DN |title=Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma (BHP RCC): A Distinctive Neoplasm Associated With Somatic NF2 Mutations |journal=Am J Surg Pathol |volume=44 |issue=7 |pages=901–916 |date=July 2020 |pmid=32217839 |pmc=7350624 |doi=10.1097/PAS.0000000000001467 |url=}}</ref> | ||
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*[[TFEB renal cell carcinoma]]. | *[[TFEB renal cell carcinoma]]. | ||
*[[Papillary renal cell carcinoma]]. | *[[Papillary renal cell carcinoma]]. | ||
*[[FH-deficient renal cell carcinoma]]. | |||
==IHC== | ==IHC== | ||