Difference between revisions of "BRCA1 interacting protein C-terminal helicase 1"

'''BRCA1 interacting protein C-terminal helicase 1''', abbreviated '''BRIP''', is a tumour suppressor gene that interacts with BRCA1 to help repair double-strand DNA breaks. <ref>URL: [https://www.ncbi.nlm.nih.gov/gene/83990 https://www.ncbi.nlm.nih.gov/gene/83990]. Accessed on: 05 March 2020.</ref> <ref name=NBK1401>URL: [https://www.ncbi.nlm.nih.gov/books/NBK1401/ https://www.ncbi.nlm.nih.gov/books/NBK1401/]. Accessed on: 05 March 2020.</ref> It is a good example of a gene whose mutations cause clinical manifestations that can be dominant or recessive.

 

It is also known as ''BACH1'' and ''FANCJ''.

*Fanconi anemia with biallelic mutations (autosomal recessive manifestation).<ref name=NBK1401/>

*Breast and ovarian cancer with monoallelic mutation (autosomal dominant manifestation).<ref name=NBK1401/>

 

*[[Familial breast cancer]].

 

 

[[Category:Gynecologic pathology]]