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Difference between revisions of "Enteropathy-associated T-cell lymphoma"
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Enteropathy-associated T-cell lymphoma (view source)
Revision as of 12:46, 9 August 2020
, 12:46, 9 August 2020former type II now classified as separate entity
(former type II now classified as separate entity) |
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| Synonyms = enteropathy-type T-cell lymphoma | | Synonyms = enteropathy-type T-cell lymphoma | ||
| Micro = large or medium-sized lymphoid cells in the mucosa and submucosa | | Micro = large or medium-sized lymphoid cells in the mucosa and submucosa | ||
| Subtypes = pleomorphic anaplastic (type I), monomorphic (type II) | | Subtypes = Historical: pleomorphic anaplastic (type I), monomorphic (type II) | ||
| LMDDx = other lymphomas | | LMDDx = other lymphomas | ||
| Stains = | | Stains = | ||
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==General== | ==General== | ||
*T cell lymphoma classically due to [[celiac sprue]]. | *T cell lymphoma classically due to [[celiac sprue]]. | ||
* | *Historically subdivided into type I and type II.<ref name=pmid21566094>{{cite journal |author=Delabie J, et al |title=Enteropathy-associated T-cell lymphoma: clinical and histological findings from the International Peripheral T-Cell Lymphoma Project|journal=Blood |volume=118|issue=148|pages= 148|year=2011|month=July}}</ref> | ||
**''Pleomorphic anaplastic'' (type I) associated with celiac sprue.<ref name=pmid17511112/> | **''Pleomorphic anaplastic'' (type I) associated with celiac sprue.<ref name=pmid17511112/> - this is now referred to as EATL since the 2017 revision of the WHO blue book 4th edition. | ||
**''Monomorphic'' (type II) not associated with celiac sprue. | **''Monomorphic'' (type II) not associated with celiac sprue - this is separate entity known as [[monomorphic epidermotropic intestinal T-cell lymphoma]]; it is no longer referred to as EATL as it is not associated with an enteropathy. | ||
*Poor prognosis.<ref name=pmid23313469>{{Cite journal | last1 = Malamut | first1 = G. | last2 = Chandesris | first2 = O. | last3 = Verkarre | first3 = V. | last4 = Meresse | first4 = B. | last5 = Callens | first5 = C. | last6 = Macintyre | first6 = E. | last7 = Bouhnik | first7 = Y. | last8 = Gornet | first8 = JM. | last9 = Allez | first9 = M. | title = Enteropathy associated T cell lymphoma in celiac disease: a large retrospective study. | journal = Dig Liver Dis | volume = 45 | issue = 5 | pages = 377-84 | month = May | year = 2013 | doi = 10.1016/j.dld.2012.12.001 | PMID = 23313469 }}</ref> | *Poor prognosis.<ref name=pmid23313469>{{Cite journal | last1 = Malamut | first1 = G. | last2 = Chandesris | first2 = O. | last3 = Verkarre | first3 = V. | last4 = Meresse | first4 = B. | last5 = Callens | first5 = C. | last6 = Macintyre | first6 = E. | last7 = Bouhnik | first7 = Y. | last8 = Gornet | first8 = JM. | last9 = Allez | first9 = M. | title = Enteropathy associated T cell lymphoma in celiac disease: a large retrospective study. | journal = Dig Liver Dis | volume = 45 | issue = 5 | pages = 377-84 | month = May | year = 2013 | doi = 10.1016/j.dld.2012.12.001 | PMID = 23313469 }}</ref> | ||
**Five-year survival as low as 20%.<ref name=pmid24876396>{{Cite journal | last1 = Pun | first1 = AH. | last2 = Kasmeridis | first2 = H. | last3 = Rieger | first3 = N. | last4 = Loganathan | first4 = A. | title = Enteropathy associated T-cell lymphoma presenting with multiple episodes of small bowel haemorrhage and perforation. | journal = J Surg Case Rep | volume = 2014 | issue = 3 | pages = | month = | year = 2014 | doi = 10.1093/jscr/rju013 | PMID = 24876396 }}</ref> | **Five-year survival as low as 20%.<ref name=pmid24876396>{{Cite journal | last1 = Pun | first1 = AH. | last2 = Kasmeridis | first2 = H. | last3 = Rieger | first3 = N. | last4 = Loganathan | first4 = A. | title = Enteropathy associated T-cell lymphoma presenting with multiple episodes of small bowel haemorrhage and perforation. | journal = J Surg Case Rep | volume = 2014 | issue = 3 | pages = | month = | year = 2014 | doi = 10.1093/jscr/rju013 | PMID = 24876396 }}</ref> | ||