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→FUSopathies (FTLD-FUS): now termed FTLD-FET
Jensflorian (talk | contribs) m (→Common diseases: FTLD-TDP) |
Jensflorian (talk | contribs) (→FUSopathies (FTLD-FUS): now termed FTLD-FET) |
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*[http://www.nature.com/nrneurol/journal/v6/n2/fig_tab/nrneurol.2009.216_F1.html Pick body (nature.com)].<ref name=pmid20139998>{{Cite journal | last1 = Grossman | first1 = M. | title = Primary progressive aphasia: clinicopathological correlations. | journal = Nat Rev Neurol | volume = 6 | issue = 2 | pages = 88-97 | month = Feb | year = 2010 | doi = 10.1038/nrneurol.2009.216 | PMID = 20139998 }}</ref> | *[http://www.nature.com/nrneurol/journal/v6/n2/fig_tab/nrneurol.2009.216_F1.html Pick body (nature.com)].<ref name=pmid20139998>{{Cite journal | last1 = Grossman | first1 = M. | title = Primary progressive aphasia: clinicopathological correlations. | journal = Nat Rev Neurol | volume = 6 | issue = 2 | pages = 88-97 | month = Feb | year = 2010 | doi = 10.1038/nrneurol.2009.216 | PMID = 20139998 }}</ref> | ||
= | =TDP Proteinopathies= | ||
=FTLD-FET= | |||
* Clinical manifestations depend on the distribution of the pathologic alterations in the CNS | * Clinical manifestations depend on the distribution of the pathologic alterations in the CNS | ||
* Currently 3 disorders among the FTLD- | * Currently 3 disorders among the FTLD-FET subgroup. | ||
* In contrast to ALS-FUS, no genetic alterations of FUS have been reported to date for cases within the FTLD-FUS group. | * In contrast to ALS-FUS, no genetic alterations of FUS have been reported to date for cases within the FTLD-FUS group. | ||
* 5–10% of all FTLD cases | |||
* Deposited Proteins: FUS, EWS, TAF-15. | |||
* FUS‐positive inclusions in FTLD cases show co‐aggregation of TAF15 and EWS | |||
**(Different from ALS-FUS) | |||
DDx (also FUS+ve): | DDx (also FUS+ve): | ||
*Spinocerebellar Ataxia (SCA) | *Spinocerebellar Ataxia (SCA) | ||
*Huntington Disease (SD) | *Huntington Disease (SD) | ||
==Atypical FTLD‐U== | |||
* Neuronal cytoplasmic inclusions in hippocampus and frontotemporal lobes. | |||
==Basophilic inclusion body disease== | ==Basophilic inclusion body disease== | ||