Difference between revisions of "Squamous cell carcinoma"

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Squamous cell carcinoma (view source)

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*Acanthosis.
*Acanthosis.


<!--
Image:
Image:
*[http://www.cmaj.ca/content/177/3/249.2/F2.expansion.html Carcinoma cuniculatum (cmaj.ca)].
*[http://www.cmaj.ca/content/177/3/249.2/F2.expansion.html Carcinoma cuniculatum (cmaj.ca)]. -->


==Verrucous squamous cell carcinoma==
==Verrucous squamous cell carcinoma==
*[[AKA]] ''verrucous carcinoma''.
*[[AKA]] ''verrucous carcinoma''.
 
{{Main|Verrucous carcinoma}}
===General===
*Good prognosis.
*Histomorphologically deceptively bland, i.e. non-malignant appearing.
*Wart-like (verruca = [[wart]]).
*The clinical history, e.g. ''huge verrucous cancer'', is often important for making the diagnosis.
 
===Microscopic===
Features:
*Exophytic growth.
*Well-differentiated.
*"Glassy" appearance.
*Pushing border - described "elephant feet".
 
DDx:
*[[Papilloma]].
*[[Wart]].
 
====Images====
*[http://www.juniordentist.com/wp-content/uploads/2011/06/Verrucous-carcinoma-histology.jpg Verrucous carcinoma (juniordentist.com)].<ref>URL: [http://www.juniordentist.com/verrucous-carcinoma.html http://www.juniordentist.com/verrucous-carcinoma.html]. Accessed on: 3 April 2012.</ref>
*[http://www.pathologyoutlines.com/images/prostate/psverrucous_scc_01.jpg Verrucous SCC (pathologyoutlines.com)].


==Spindle cell squamous carcinoma==
==Spindle cell squamous carcinoma==
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*[[p63]] +ve.
*[[p63]] +ve.
*K903 +ve.
*K903 +ve.
*p16 +ve/-ve -- dependent on site, +ve favours non-lung SCC.<ref name=pmid20823766/>
*[[p16]] +ve/-ve -- dependent on site, +ve favours non-lung SCC.<ref name=pmid20823766/>
*[[p40]] +ve.
 
Note:
*Immunostains not particularly helpful for establishing primary site of squamous cell carcinoma. p16 may be helpful but is not definitive for non-lung SCC.<ref name=pmid20823766/>


=See also=
=See also=
*[[Adenocarcinoma]].
*[[Adenocarcinoma]].
*[[Pseudoepitheliomatous hyperplasia]] - can mimic squamous cell carcinoma.
*[[Basics]].
*[[Basics]].


Michael
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