48,830
edits
Difference between revisions of "Epidermal growth factor receptor inhibitors"
Jump to navigation
Jump to search
Epidermal growth factor receptor inhibitors (view source)
Revision as of 19:34, 8 November 2018
, 19:34, 8 November 2018→Drugs
(→Drugs) |
(→Drugs) |
||
| Line 4: | Line 4: | ||
First generation: | First generation: | ||
*[[Gefitinib]] (Iressa).<ref name=pmid20855837/> | *[[Gefitinib]] (Iressa).<ref name=pmid20855837/> | ||
*[[Erlotinib]] (Tarceva).<ref name=pmid20855837>{{cite journal |author=Sun Y, Ren Y, Fang Z, ''et al.'' |title=Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases |journal=J. Clin. Oncol. |volume=28 |issue=30 |pages=4616–20 |year=2010 |month=October |pmid=20855837 |doi=10.1200/JCO.2010.29.6038 |url=}}</ref> | *[[Erlotinib]] (''Tarceva'' Roche).<ref name=pmid20855837>{{cite journal |author=Sun Y, Ren Y, Fang Z, ''et al.'' |title=Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases |journal=J. Clin. Oncol. |volume=28 |issue=30 |pages=4616–20 |year=2010 |month=October |pmid=20855837 |doi=10.1200/JCO.2010.29.6038 |url=}}</ref> | ||
*Afatinib (Gilotrif) - esp. effective when del19 is present.<ref>{{Cite journal | last1 = Yang | first1 = JC. | last2 = Wu | first2 = YL. | last3 = Schuler | first3 = M. | last4 = Sebastian | first4 = M. | last5 = Popat | first5 = S. | last6 = Yamamoto | first6 = N. | last7 = Zhou | first7 = C. | last8 = Hu | first8 = CP. | last9 = O'Byrne | first9 = K. | title = Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials. | journal = Lancet Oncol | volume = 16 | issue = 2 | pages = 141-51 | month = Feb | year = 2015 | doi = 10.1016/S1470-2045(14)71173-8 | PMID = 25589191 }}</ref> | *Afatinib (Gilotrif) - esp. effective when del19 is present.<ref>{{Cite journal | last1 = Yang | first1 = JC. | last2 = Wu | first2 = YL. | last3 = Schuler | first3 = M. | last4 = Sebastian | first4 = M. | last5 = Popat | first5 = S. | last6 = Yamamoto | first6 = N. | last7 = Zhou | first7 = C. | last8 = Hu | first8 = CP. | last9 = O'Byrne | first9 = K. | title = Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials. | journal = Lancet Oncol | volume = 16 | issue = 2 | pages = 141-51 | month = Feb | year = 2015 | doi = 10.1016/S1470-2045(14)71173-8 | PMID = 25589191 }}</ref> | ||
Second generation: | Second generation: | ||