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Difference between revisions of "Vulva"
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→Lichen sclerosus: more
(→Lichen sclerosus: expand/merge with skin section) |
(→Lichen sclerosus: more) |
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===General=== | ===General=== | ||
*Associated with differentiated vulvar intraepithelial neoplasia. | |||
**Approximately 50% of vulvar cancer associated with lichen sclerosus. | |||
Clinical: | |||
*Pruritis -> leads to scratching. | *Pruritis -> leads to scratching. | ||
* | *Chronic condition. | ||
*Usu. post-menopausal women. | |||
*May lead to labial fusion. | |||
Treatment: | |||
*Steroids - high dose initially, then a maintenance therapy to prevent relapse. | |||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref>URL: [http://www.pathologyoutlines.com/vulva.html#lichensclerosis http://www.pathologyoutlines.com/vulva.html#lichensclerosis]. Accessed on: 19 April 2011.</ref> | Features:<ref>URL: [http://www.pathologyoutlines.com/vulva.html#lichensclerosis http://www.pathologyoutlines.com/vulva.html#lichensclerosis]. Accessed on: 19 April 2011.</ref> | ||
*Loss of rete ridges | *Loss of rete ridges. | ||
*Severe hyperkeratosis. | *Severe hyperkeratosis. | ||
*Fibrosis of dermis with loss of adnexal structures. | *Fibrosis of dermis with loss of adnexal structures - '''key feature'''. | ||
*Inflammation - often with eosinophils. | *Inflammation - often with eosinophils. | ||