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Difference between revisions of "Vulva"
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**''Differentiated VIN'' is mostly irrelevant as it is basically never seen alone, i.e. it usually accompanies cancer. | **''Differentiated VIN'' is mostly irrelevant as it is basically never seen alone, i.e. it usually accompanies cancer. | ||
==Classic | ==Classic vulvar intraepithelial neoplasia== | ||
===Epidemiology=== | ===Epidemiology=== | ||
*Classic VIN, like CIN, is associated with [[HPV]] and seen in younger women. | *Classic VIN, like CIN, is associated with [[HPV]] and seen in younger women. | ||
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**Most caused by HPV. | **Most caused by HPV. | ||
===Microscopic | ===Microscopic=== | ||
Features: | |||
*Increased NC ratio. | *Increased NC ratio. | ||
*Multinucleation. | *Multinucleation. | ||
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*Apical mitoses. | *Apical mitoses. | ||
==Differentiated | ==Differentiated vulvar intraepithelial neoplasia== | ||
===Epidemiology=== | ===Epidemiology=== | ||
*Associated with [[lichen sclerosus]]. | *Associated with [[lichen sclerosus]]. | ||
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===General=== | ===General=== | ||
*Pruritis -> leads to scratching. | *Pruritis -> leads to scratching. | ||
*Associated with differentiated vulvar intraepithelial neoplasia. | |||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref>[http://www.pathologyoutlines.com/vulva.html#lichensclerosis http://www.pathologyoutlines.com/vulva.html#lichensclerosis]</ref> | Features:<ref>URL: [http://www.pathologyoutlines.com/vulva.html#lichensclerosis http://www.pathologyoutlines.com/vulva.html#lichensclerosis]. Accessed on: 19 April 2011.</ref> | ||
*Loss of rete ridges - '''key feature'''. | *Loss of rete ridges - '''key feature'''. | ||
*Severe hyperkeratosis. | *Severe hyperkeratosis. | ||
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*[[Gynecologic pathology]]. | *[[Gynecologic pathology]]. | ||
*[[Uterus]]. | *[[Uterus]]. | ||
*[[Cervix]] - cervical intraepithelial neoplasia. | *[[Cervix]] - cervical intraepithelial neoplasia (CIN). | ||
*[[Vagina]]. | *[[Vagina]]. | ||
*[[Anus]] - anal intraepithelial neoplasia. | *[[Anus]] - anal intraepithelial neoplasia. | ||